مقالات علمية مخبر

البيولوجيا: تطبيقات في الصحة والمحيط

نشر باحثو المخبر خلال الفترة 2021–2026 أكثر من خمسين مقالاً علمياً، أغلبها في مجلات دولية محكّمة. وتعكس هذه الأعمال تنوّع محاور البحث في المخبر، وتشمل عدة تعاونات مع فرق بحث وطنية ودولية.

المقالات العلمية

2026
  1. Chabane, S., Boudjelal, A., Demirtas, I., Bouchahdane, S., Tail, G., Yenigün, S., Ozen, T., Yıldız, I., Amrane, A. (2026). LC-ESI-MS/MS-based phytochemical profiling and pharmacological validation of Centaurium erythraea Rafn (Gentianaceae) traditionally used for pain and inflammation. Journal of Ethnopharmacology, 360, 121135. https://doi.org/10.1016/j.jep.2025.121135
  2. Timizar, Z., Hadj Ziane Zafour, A., Rahim, I., Lekmine, S., Laribi, H., Telili, M. L., Boutemak, K., Belkadi, A., Boudjelal, A., Zhang, J., Amrane, A., Tahraoui, H. (2026). Development and healing potential of a transdermal patch with nanoemulsion from Teucrium polium L. ethanolic extract. Euro-Mediterr J Environ Integr, 11, 68. https://doi.org/10.1007/s41207-025-01028-1
  3. Bouchahdane, S., Boumendjel, M., Boudjelal, A., et al. (2026). LC-ESI-MS/MS Analysis, Antioxidant Activity, DNA-Protective Effects, and Antiproliferative Potential of the Hydromethanolic Leaf Extract of Hypericum androsaemum L. ChemistrySelect, 11(22), e07036. https://doi.org/10.1002/slct.202507036
  4. Chabane, S., Boudjelal, A., Pulvirenti, L., Kocaman, A. Y., Demirtas, I., Yıldız, İ., Gül, F., Çelik, S. M., Abdeltif, A. (2026). Multitarget Antiproliferative Activity of Pituranthos scoparius: An Integrated Phytochemical, Biological and Computational Insights into Key Oncogenic Pathways. Molecules, 31(15), 2561. https://doi.org/10.3390/molecules31152561
  5. Bouzid, Dj., Smeriglio, A., Imbesi, M., Boudjelal, A., Merzouki, S., Trombetta, D. (2026). Dose-tunable solvent-free ozonation of extra virgin olive oil: exposure-defined chemical remodelling and sustainability-oriented process standardization. Sustainable Chemistry and Pharmacy, 53. https://doi.org/10.1016/j.scp.2026.102567
  6. Allouani, M., Moutassem, D., Hendel, N., D’Anneo, A., Boulila, A., M’rabet, Y., Chaâbane, H., Boudjelal, A., Pratelli, G., Amata, S., Rizzo, C., Bellik, Y., Palumbo Piccionello, A. (2026). Phytochemical Profiling and Antioxidant, Anticancer, and Antimicrobial Activities of Lavandula multifida L. Extracts. Molecules, 31(18), 3144. https://doi.org/10.3390/molecules31183144
  7. Rahmoune, I., Karoune, S., Azzam, C., Saad, S., Hendel, N., Toka, H., Chebrouk, F., Cheriet, T., Kechebar, M. S., Mizab, O. (2026). First report on cultivated Salvia hispanica in an arid climate: UPLC-MS/MS analysis, antioxidant, and enzymatic activities. Journal of the Mexican Chemical Society, e2485. https://doi.org/10.29356/jmcs.v70i1.2485

2025

  1. Bouafia, Z., Boudjelal, A., Bouaziz-Terrachet, S., Smeriglio, A., Bouhenna, M. M., Yıldız, I., Demirtas, I., Trombetta, D. (2025). In Vivo Wound-Healing and Molecular Docking Studies Support the Traditional Use of Arisarum vulgare Aqueous Extract. Phytotherapy Research, 1–19. https://doi.org/10.1002/ptr.70087
  2. Derradji, L., Benkhaled, A., Yıldız, K., Özbek, Z. A., Nouasri, A., Ergönül, P. G. (2025). Influence of Extraction Method on Physicochemical Properties, Fatty Acid Profile, and Tocol Content of Pistacia lentiscus Oil From the Hodna Subarid Region (Algeria). Chemistry & Biodiversity, e01018. https://doi.org/10.1002/cbdv.202501018
  3. Ladjel-Mendil, A., Amarni, M., Chelghoum, H., Lacheheb, S., Abou Mustapha, M., Chebrouk, F., Boudjelal, A., Kebir, M., Krishna Kumar, Y., Darwish, H., Yacine, B., Amrane, A., Tahraoui, H. (2025). Essential oil from aerial parts of Salvia sclarea: A comprehensive study of antibacterial activity through chemical profiling, molecular interactions, and predictive modeling using QSAR_KNN_PCA. Journal of Essential Oil Bearing Plants, 28(5), 902–919. https://doi.org/10.1080/0972060X.2025.2559656
  4. Allouani, M., Hendel, N., Moutassem, D., Sarri, M., Sarri, D., D’Anneo, A., Gallo, G., Palumbo Piccionello, A. (2025). Traditional Applications, Phytochemical Constituents, and Pharmacological Properties of Lavandula multifida L.: A Review. Molecules, 30(19), 3906. https://doi.org/10.3390/molecules30193906
  5. Allouani, M., Hendel, N., Moutassem, D., Madani, S., Sarri, D., Kherbache, A., Sahraoui, M. (2025). Otospermum glabrum extracts: antioxidant properties and bioactivity against fungal pathogens and Aphis fabae. Plant Protection Bulletin, 65(3), 69–81. https://doi.org/10.16955/bitkorb.1613134
  6. Brahimi, H. A., Oulebsir-Mohandkaci, H., Hendel, N., Sarri, M. (2025). Ethnobotanical knowledge and traditional uses of propolis among the Algerian population: a comparative and multivariate analysis. Ethnobotany Research and Applications, 31, 1–18. http://dx.doi.org/10.32859/era.31.57.1-18
  7. Juvé, Y., Weyna, A., Lauroua, E., Nidelet, S., Khaldi, M., Barech, G., et al. (2025). Phylogenomics of Messor harvester ants (Hymenoptera: Formicidae: Stenammini) unravels their biogeographical origin and diversification patterns. Systematic Entomology, 50(4), 1025–1040. https://doi.org/10.1111/syen.12693
  8. Hamecha, L., Barech, G., Ali Ahmed, D., Khaldi, M., Schifani, E., et al. (2025). Estimating the Taxonomic Richness and Functional Structure of Ant Communities in Olive Groves of Kabylia, Algeria. African Journal of Ecology, 63(7), e70106. https://doi.org/10.1111/aje.70106

2024

  1. Harrar, A., Hamat, R. A., Hamidechi, M. A. (2024). Bioinformatics analysis and spatiotemporal distribution of the fliC gene and its protein isolated from Escherichia coli-infected patients in Eastern Algeria. Malays J Med Sci, 31(5), 161–195. https://doi.org/10.21315/mjms2024.31.5.12
  2. Benbelkhir, F. Z., Allali, K., Benadjila, A., Goudjal, Y., Medjekal, S., Zamoum, M. (2024). Development of bioinsecticide based on Streptomyces griseoflavus PAL114 for control of black bean aphids Aphis fabae. Biocontrol Science and Technology, 34(8), 736–753. https://doi.org/10.1080/09583157.2024.2373477
  3. Bouafia, Z., Boudjelal, A., Bouaziz-Terrachet, S., Bouhenna, M. M., Bouchahdane, S., Boulila, A., Yıldız, I., Yılmaz, S., Ozen, T., Demirtas, I. (2024). Arisarum vulgare: Bridging Tradition and Science Through Phytochemical Characterization and Exploring Therapeutic Potential via In vitro, In vivo and In silico Biological Activities. ChemistrySelect, 9(38). https://doi.org/10.1002/slct.202402754
  4. Aouina, N. Y., Benkhaled, A., Boudjelal, A. (2024). Exploring FTIR Spectroscopy as promising tool for Analyzing Cancer Biomarkers: A Comprehensive Review. Agricultural Mechanization in Asia, Africa and Latin America, 55(08).
  5. Baali, F., Boudjelal, A., Smeriglio, A., Righi, N., Djemouai, N., Deghima, A., Bouafia, Z., Trombetta, D. (2024). Phlomis crinita Cav. from Algeria: A source of bioactive compounds possessing antioxidant and wound healing activities. Journal of Ethnopharmacology, 331, 118295. https://doi.org/10.1016/j.jep.2024.118295
  6. Adili, N., Oucheriah, Y., Belabbas, H. (2024). Prevalence of Fasciola hepatica and Echinococcus granulosus in slaughtered cattle, sheep, and goats in El-Hodna region (center of Algeria). Brazilian Journal of Animal and Environmental Research, 7(1), 740–750. https://doi.org/10.34188/bjaerv7n1-057
  7. Adili, N., Oucheriah, Y., Belabbas, H., Boulahia, A., Hamami, A., Merabti, I. (2024). Morphometric Study of Red Blood Cells in the Dromedary Camel (Camelus dromedarius). Brazilian Journal of Animal and Environmental Research, 7(2), e68715. https://doi.org/10.34188/bjaerv7n2-001
  8. Oucheriah, Y., Adili, N., Belabbas, H., Bdirina, M., Guerbi, D., Guettala, S. (2024). Study of the physico-chemical and microbiological characteristics of goat’s milk from the local Arbia breed, Algeria. Brazilian Journal of Animal and Environmental Research, 7(3), e71692. https://doi.org/10.34188/bjaerv7n3-035
  9. Hendel, N., Sarri, D., Sarri, M., Ali Ghafsi, A., Benseghir, A. (2024). Polyphenolic contents, antioxidant, and antimicrobial activities of Saccocalyx satureioides Coss. & Dur. essential oil and methanol extracts. An. Acad. Bras. Cienc., 96, e20240703. https://doi.org/10.1590/0001-3765202420240703
  10. Hendel, N., Sarri, D., Sarri, M., Napoli, E., Palumbo Piccionello, A., Ruberto, G. (2024). Phytochemical analysis and antioxidant and antifungal activities of powders, methanol extracts, and essential oils from Rosmarinus officinalis L. and Thymus ciliatus Desf. Benth. International Journal of Molecular Sciences, 25, 7989. https://doi.org/10.3390/ijms25147989
  11. Kheloufi, M., Sarri, M., Hendel, N., Sarri, D. (2024). Chemical composition, anti-fusarium and radical-scavenging activities of essential oil and extracts of Hertia cheirifolia (L.) Kuntze growing in Boutaleb (Setif, Algeria). Agr. Acad. J., 7(2), 1–9. https://doi.org/10.32406/v7n2/2024/1-9/agrariacad
  12. Hendel, N., Sarri, M., Sarri, D., Seghiour, S., Napoli, E., Selloum, M., Ruberto, G. (2024). Phytochemical analysis, antibacterial and antifungal effect of Lavandula dentata L. essential oil and methanol extract. Natural Product Research, 38(20), 3498–3507. https://doi.org/10.1080/14786419.2023.2252973
  13. Chetehouna, S., Derouiche, S., Reggami, Y., Boulaares, I. (2024). Sonchus maritimus Extract-Loaded Niosomes Bioconjugated by Linoleic Acid in Hepatic Encephalopathy Induced by High-Fructose Diet in Albino Wistar Rats. Archives of Razi Institute, 79(1), 194–205. https://doi.org/10.32592/ARI.2024.79.1.194
  14. Chetehouna, S., Derouiche, S., Boulaares, I., Reggami, Y. (2024). Phytochemical profile, anti-inflammatory analysis and cytotoxic activity of SmE-SeNPs against breast (MCF-7) cancer cells. Biocatalysis and Agricultural Biotechnology, 57, 103122. https://doi.org/10.1016/j.bcab.2024.103122
  15. Chetehouna, S., Derouiche, S., Reggami, Y., Boulaares, I., Frahtia, A. (2024). Gas Chromatography Analysis, Mineral Contents and Anti-inflammatory Activity of Sonchus maritimus. Tropical Journal of Natural Product Research, 8(4), 6787–6798. https://doi.org/10.26538/tjnpr/v8i4.7
  16. Chetehouna, S., Derouiche, S., Reggami, Y. (2024). Green Chemistry Approaches towards the Synthesis of Selenium Nanoparticles (SeNPs) as a Metal Nano-Therapy: Possible Mechanisms of Anticancer Action. Frontiers in Biomedical Technologies, 11(3), 509–529. https://doi.org/10.18502/fbt.v11i3.15894
  17. Mekki, G., Barech, G., Khaldi, M. (2024). Biodiversité des communautés de mouches des fruits (Diptera, Tephritidae) et dynamique des populations de Ceratitis capitata dans un agroécosystème de grenadier à M’sila (Algérie). Boletín de la Asociación Española de Entomología, 48(3-4), 205–218. https://doi.org/10.70186/BAEEMMCN2266
  18. Agrane, S., Mahdi, K., Saada, I., Ammouche, Z., Grine, S., Cherief, A., Boutera, N., Mimeche, F. (2024). Chemical composition and insecticidal toxicity of Artemisia arborescens and Rosmarinus tournefortii essential oils against two major coleopteran pests. South-Western Journal of Horticulture, Biology and Environment, 15(2), 113–122.

2023

  1. Keller, M., Chabane, S., Boudjelal, A., Danton, O., Prescimone, A., Hamburger, M., Potterat, O. (2023). New neo-clerodane diterpenes from Teucrium polium subsp. capitatum. Journal of Molecular Structure, 135447. https://doi.org/10.1016/j.molstruc.2023.135447
  2. Chabane, S., Boudjelal, A., Bouaziz-Terrachet, S., Spinozzi, E., Maggi, F., Petrelli, R., Tail, G. (2023). Analgesic effect of Centaurium erythraea and molecular docking investigation of the major component swertiamarin. Natural Product Research, 38(24), 4511–4517. https://doi.org/10.1080/14786419.2023.2278160
  3. Sarri, M., Fodil, H., Hendel, N., Sarri, D., Bruno, M., Maggi, F. (2023). Essential oil of Apium nodiflorum (L.) Lag. growing in Ksob River, Algeria. Natural Product Research, 1–4. https://doi.org/10.1080/14786419.2023.2297855
  4. Sarri, M., Aiche, H., Choubar, S., Sarri, D., Hendel, N. (2023). The urban biodiversity of M’sila city (Algeria). Journal of EcoAgriTourism, 19(1), 13–20.
  5. Chetehouna, S., Derouiche, S., Reggami, Y. (2023). Green synthesis of SeNPs using Sonchus maritimus based nanosized metal oxides for in vitro biological applications and in vivo acute toxicity evaluation. Kragujevac Journal of Science, 45, 65–78. https://doi.org/10.5937/KgJSci2345065C

2022

  1. Boudjelal, A., Napoli, E., Benkhaled, A., Benazi, L., Bey, R., Gentile, D., Ruberto, G. (2022). In vivo wound healing effect of Italian and Algerian Pistacia vera L. resins. Fitoterapia, 159, 105197. https://doi.org/10.1016/j.fitote.2022.105197
  2. Kheniche, A., Kadi, I., Benslama, A., Rizoug, S., Bekri, S., Harrar, A. (2022). Effect of Bridging Atom and Hydroxyl Position on the Antioxidant Capacity of Six Phenolic Schiff Bases. Indones. J. Chem., 22(5), 1233–1245. https://doi.org/10.22146/ijc.72379
  3. Nabti, L. Z., Sahli, F., Olowo-okere, A., Benslama, A., Harrar, A., Lupande-Mwenebitu, D., Diene, S., Rolain, J. (2022). Molecular Characterization of Clinical Carbapenem-Resistant Enterobacteriaceae Isolates from Sétif, Algeria. Microbial Drug Resistance, 28(3), 274–279. https://doi.org/10.1089/mdr.2021.0123
  4. Benbelkhir, F. Z., Medjekal, S. (2022). Microalgal carotenoids: A promising alternative to synthetic dyes. Algal Research, 66, 102823. https://doi.org/10.1016/j.algal.2022.102823
  5. Sassoui, A., Sarri, D., Hendel, N., Sarri, M. (2022). Traditional uses, phytochemical and biological activities of Pulicaria arabica (L.) Cass. Journal of EcoAgriTourism, 18(1), 30–35.
  6. Aouari, I., Barech, G., Khaldi, M. (2022). First record of the agricultural pest Drosophila suzukii (Matsumura, 1931) (Diptera: Drosophilidae) in Algeria. EPPO Bulletin, 52(2), 471–478. https://doi.org/10.1111/epp.12866

2021

  1. Napoli, E., Boudjelal, A., Benkhaled, A., Chabane, S., Gentile, D., Ruberto, G. (2021). Chemical composition, safety and efficacy of Pistacia vera L. oleoresin essential oils in experimental wounds. Journal of Essential Oil Research, 33(5), 464–470. https://doi.org/10.1080/10412905.2021.1917460
  2. Chabane, S., Boudjelal, A., Napoli, E., Benkhaled, A., Ruberto, G. (2021). Phytochemical composition, antioxidant and wound healing activities of Teucrium polium subsp. capitatum (L.) Briq. essential oil. Journal of Essential Oil Research. https://doi.org/10.1080/10412905.2020.1842260
  3. Benslama, A., Daci, S., Nabti, L. Z., Bendif, H., Harrar, A. (2021). Assessment of polyphenols contents, antibacterial and antioxidant activities of Origanum majorana extracts. European Journal of Biological Research, 11(4), 509–518. http://dx.doi.org/10.5281/zenodo.5608519
  4. Baali, F., Boumerfeg, S., Boudjelal, A., Denaro, M., Ginestra, G., Baghiani, A., Righi, N., Deghima, A., Benbacha, F., Smeriglio, A., Trombetta, D. (2021). Wound-healing activity of Algerian Lavandula stoechas and Mentha pulegium extracts: from traditional use to scientific validation. Plant Biosystems, 156(2), 427–439. https://doi.org/10.1080/11263504.2020.1869117
  5. Fodil, H., Sarri, M., Hendel, N., Sarri, D. (2021). Potentiality of medicinal flora in treating of several diseases in some municipalities in the Hodna (Algeria). Journal of EcoAgriTourism, 17(2), 44–53.
  6. Hendel, N., Djamel, S., Madani, S., Selloum, M., Boussakra, F., Driche, O. (2021). Screening for in vitro antioxidant activity and antifungal effect of Artemisia campestris L. International Journal of Agriculture Environment and Food Sciences, 5(3), 251–259. http://doi.org/10.31015/jaefs.2021.3.1
  7. Khaldi, M., Barech, G., Bendjedou, H., Aouari, I. (2021). First detection and infestation levels of the invasive fruit fly Zaprionus indianus Gupta, 1970 (Diptera: Drosophilidae) in pomegranate orchards from Algeria. African Entomology, 29(1), 173–179. https://doi.org/10.4001/003.029.0173
  8. Abdi-Hamecha, L., Barech, G., Khaldi, M., Ali-Ahmed Sadoudi, D., Salem, S., Zazgad, I., Cagniant, H. (2021). Diversité des fourmis (Hymenoptera, Formicidae) dans la forêt de Yakouren (Algérie) : estimation de la richesse, biogéographie et taxonomie. Revue suisse de Zoologie, 128(1), 61–72. https://doi.org/10.35929/RSZ.0035